Abin da kuke Bukatar Ku sani Game da Barci da Alzheimer's

Ina aiki kowace rana don kiyaye kwakwalwata cikin tsari mai kyau. Na karanta, Ina wasa da yara na (Kalmomi tare da Abokai, kowa?), Supplementsauki kari, kuna suna. Ina cin abincin da ke jaddada abincin kwakwalwa -gami da waɗancan omega 3s da na rubuta game da su kwanan nan. Ina kuma tabbatar da samun bacci mai yawa.

Ina aiki tuƙuru a yau don ƙwarewar fahimtata ta kasance mai ƙarfi shekaru da yawa akan hanya.

Amma yin rayuwa mai ƙoshin lafiya ba zai nisanta mu daga damuwa game da haɗarin na dogon lokaci don raguwar hankali da cututtukan neurodegenerative kamar dementia. Yawancin marasa lafiya na da ke motsawa ta tsakiyar shekaru suna magana da ni game da tsoronsu na rasa ƙwaƙwalwar ajiya, tsarkin tunani, da ayyukan fahimi tare da shekaru - da damuwar su game da cutar Alzheimer musamman.

Akwai sabon bincike game da hanyar haɗin gwiwa tsakanin bacci da cutar Alzheimer Ina so in raba tare da ku - binciken da ke zurfafa fahimtarmu kan yadda ake haɗar bacci mara kyau da cutar Alzheimer. Yawancin mu tabbas mun sani, ko mun san wani, wanda cutar Alzheimer ta shafa. Abin takaici, lambobi suna nuna hakan. A cewar Ƙungiyar Alzheimer, wani a Amurka yana kamuwa da cutar Alzheimer kowane sakan 65. A yau, akwai Amurkawa miliyan 5.7 da ke rayuwa tare da wannan cutar neurodegenerative - mafi yawan nau'in rashin hankali. Zuwa shekarar 2050, alkaluma sun yi hasashen cewa adadin zai haura miliyan 14.

Me ke kawo cutar Alzheimer?

Amsar mai wuya ita ce, ba mu sani ba tukuna. Masana kimiyya suna aiki tukuru don gano abubuwan da ke haifar da cutar Alzheimer. Kodayake har yanzu ba mu san dalilin ba, abin da muka sani shi ne cewa cutar tana haifar da manyan matsaloli a yadda ƙwayoyin kwakwalwa ke aiki.

Biliyoyin neurons a cikin kwakwalwarmu koyaushe suna aiki, suna rayar da mu da aiki. Suna ba mu damar yin tunani da yanke shawara, adanawa da dawo da ƙwaƙwalwa da koyo, dandana duniyar da ke kewaye da mu ta hankulan mu, jin dukkan motsin zuciyar mu, da bayyana kan mu cikin yare da ɗabi'a.

Masana kimiyya suna tunanin akwai nau'ikan adadi mai yawa na furotin waɗanda ke haifar da lalacewar ƙwayoyin kwakwalwa, wanda ke haifar da matsalolin da ke ci gaba da ƙaruwa tare da ƙwaƙwalwa, koyo, yanayi, da ɗabi'a - alamun alamun cutar Alzheimer. Biyu daga cikin waɗannan sunadaran sune:

• Beta-amyloid sunadarai, waɗanda ke ginawa don yin filaye a kusa da ƙwayoyin kwakwalwa.
• Tau sunadarai, waɗanda ke haɓakawa zuwa ƙulli kamar fiber-wanda aka sani da tangles-a cikin ƙwayoyin kwakwalwa.

Masana kimiyya har yanzu suna aiki don fahimtar yadda faranti da tangles ke ba da gudummawa ga cutar Alzheimer da alamunta. Tare da shekaru, ya zama gama gari ga mutane su haɓaka wasu daga cikin waɗannan abubuwan gina jiki a cikin kwakwalwa. Amma mutanen da ke da cutar Alzheimer suna haɓaka filaye da tangal -tangal cikin adadi mai yawa - musamman a yankunan kwakwalwa da ke da alaƙa da ƙwaƙwalwa da sauran ayyuka masu rikitarwa.

Akwai ci gaban binciken da ke nuna rashin ingantaccen bacci da rashin samun isasshen bacci suna da alaƙa da adadin beta-amyloid da furotin tau a cikin kwakwalwa. Studyaya daga cikin binciken da aka saki a cikin 2017 ya gano cewa a cikin masu lafiya, tsofaffi masu matsakaicin shekaru, rikice-rikice don jinkirin bacci yana da alaƙa da haɓaka matakan sunadarai beta-amyloid.

Barcin rana yana da alaƙa da adadin furotin da ke da alaƙa da kwakwalwa a cikin kwakwalwa

Wani binciken da aka saki kawai ya nuna cewa yawan baccin rana yana da alaƙa da adadi mai yawa na kwakwalwar furotin beta-amyloid a cikin tsofaffi masu lafiya. Masana kimiyya a Asibitin Mayo sun tashi a cikin binciken su don amsa babbar tambaya game da sanadi: shin gina furotin beta-amyloid yana ba da gudummawa ga bacci mara kyau, ko rushewar bacci yana haifar da tarin waɗannan sunadaran?

Asibitin Mayo ya riga ya ci gaba da binciken dogon lokaci game da canjin fahimi da ke tattare da tsufa. Daga wannan binciken da ke gudana, masana kimiyya sun zaɓi mutane 283, waɗanda suka haura shekaru 70 kuma ba su da tabin hankali, don bincika alaƙar da ke tsakanin yanayin bacci da aikin furotin beta-amyloid.

A farkon binciken, kusan kashi ɗaya cikin huɗu-kaɗan fiye da kashi 22 cikin ɗari na manya a cikin rukunin sun ba da rahoton cewa sun sami baccin rana da yawa.Kasancewa da yawan bacci yayin rana shine, ba shakka, babban alamar cewa ba ku samun isasshen bacci da dare - kuma alama ce da ke da alaƙa da rikicewar bacci na yau da kullun, gami da rashin bacci.

Fiye da shekaru bakwai, masana kimiyya sun kalli ayyukan beta-amyloid na marasa lafiya ta amfani da binciken PET. Sun gano:

Mutanen da ke yawan bacci da rana a farkon binciken sun fi samun ƙarin matakan beta-amyloid akan lokaci.

A cikin waɗannan mutanen da ke hana bacci, adadi mai yawa na haɓaka beta-amyloid ya faru a cikin ɓangarorin kwakwalwa guda biyu: cingulate na gaba da madaidaicin madaidaiciya. A cikin mutanen da ke da cutar Alzheimer, waɗannan ɓangarorin biyu na kwakwalwa suna nuna babban matakan gina beta-amyloid.

Wannan binciken bai ba da tabbataccen amsar tambayar ko rashin bacci ne ke haifar da gina furotin amyloid, ko ajiyar amyloid da ke haifar da matsalolin bacci - ko wasu biyun. Amma yana ba da shawarar cewa yawan bacci da rana yana iya zama alamar gargaɗin farkon cutar Alzheimer.

Nazarin Mayo Clinic yayi layi tare da ƙarin binciken kwanan nan wanda ya kalli alaƙar da ke tsakanin rashin bacci da haɗarin Alzheimer. Masana kimiyya a Jami'ar Wisconsin, Madison sun bincika yuwuwar alaƙa tsakanin ingancin bacci da wasu mahimman alamomi don Alzheimer's, wanda aka samu a cikin ruwan kashin baya, gami da alamomin furotin beta-amyloid da furotin tau waɗanda ke haifar da tangles na jijiya.

A cikin wannan binciken, masana kimiyya sun gwada mutane ba tare da Alzheimer ko dementia ba - amma musamman sun zaɓi mutanen da ke cikin haɗarin kamuwa da cutar, ko dai saboda suna da iyaye tare da Alzheimer ko kuma saboda suna ɗauke da takamaiman gene (apolipoprotein E gene), wanda yana da nasaba da cutar.

Kamar takwarorinsu na Mayo, masu binciken Madison sun gano cewa mutanen da suka sami baccin rana da yawa sun nuna ƙarin alamun furotin beta-amyloid. Sun kuma sami baccin rana yana da alaƙa da ƙarin alamomi don furotin tau. Kuma mutanen da suka ba da rahoton bacci mara kyau kuma waɗanda ke da yawan matsalolin bacci sun nuna yawancin abubuwan da ke haifar da cutar Alzheimer fiye da takwarorinsu masu bacci.

Kwakwalwa tana wanke kanta daga sunadaran da ke da alaƙa da Alzheimer yayin bacci

A 'yan shekarun da suka gabata ne masana kimiyya suka gano wani tsarin da ba a san shi ba a cikin kwakwalwa wanda ke share shara, gami da sunadaran beta-amyloid da ke da alaƙa da cutar Alzheimer. (Jami'ar Rochester Medical Center masana kimiyya waɗanda suka yi wannan binciken sun sanya masa suna "tsarin glymphatic," saboda yana aiki da yawa kamar tsarin ƙwayoyin lymph na jiki don cire datti daga jiki, kuma sel ɗin glial na kwakwalwa ke sarrafa shi.) Masana kimiyya ba su ' t kawai gano tsarin glymphatic - wani bincike mai zurfi a ciki da kansa. Sun kuma gano cewa tsarin glymphatic yana shiga cikin wuce gona da iri yayin bacci.

Lokacin da muke bacci, masanan kimiyya sun gano, tsarin glymphatic ya zama mai aiki sau goma wajen share shara daga kwakwalwa.

Wannan shine mafi yawan bincike mai tursasawa tukuna don nuna mahimmancin bacci mai lafiya ga lafiyar kwakwalwa na dogon lokaci. Lokacin da kuke bacci, masana kimiyya yanzu suna tunanin, tsarin glymphatic ɗin ku yana haɓaka ayyukan sa don cire tarkace mai haɗari wanda ya tattara akan ranar farkawa. Idan kuna bacci mara kyau ko kuna tafiya ba tare da isasshen bacci akai -akai ba, kuna haɗarin rasa cikakken tasirin wannan aikin tsarkakewa.

Hanyoyin farkawa na bacci ba daidai ba suna da alaƙa da cutar Alzheimer

Wata alama mai alamar alaƙar gargaɗin farkon cutar Alzheimer? Rikicin yanayin bacci, a cewar sabon bincike. Masana kimiyya a Makarantar Magunguna ta Jami'ar Washington sun bi sahun circadian da hawan bacci na kusan tsofaffi 200 (matsakaicin shekaru, 66), kuma sun gwada su duka da wuri, alamun farko na asibiti na cutar Alzheimer.

A cikin marasa lafiya 50 da suka nuna alamun cutar Alzheimer na farko-farko, duk sun tarwatsa hanyoyin farkar da bacci. Wannan yana nufin jikinsu baya bin tsarin abin dogaro na barcin dare da ayyukan rana. Sun sami damar yin bacci kaɗan da daddare, kuma sun fi karkata da yin bacci da rana.

Wani abu mai mahimmanci da za a lura da shi anan: Mutanen da ke cikin binciken waɗanda suka tarwatsa hanyoyin farkar da bacci ba duka bacci ya hana su ba. Suna samun isasshen bacci-amma suna tara bacci cikin yanayin rarrabuwa a cikin awanni 24.

Wannan binciken yana ba da shawarar cewa rudani na rudun circadian na iya zama farkon yanayin halittar Alzheimer, ko da babu rashi na bacci.

Lokacin da marasa lafiya na ke raba min damuwar su game da lafiyar su na dogon lokaci da tsoron su na Alzheimer, na fahimta. Zan gaya muku abin da na gaya musu: mafi kyawun abin da za ku iya yi shi ne ku fassara damuwar ku zuwa aikin rigakafin kuma ku kula da kanku a yau, tare da manufar rage haɗarin ku don raguwar hankali da rashin hankali. Idan aka kalli duk abin da muka sani, a bayyane yake cewa samun wadataccen bacci mai inganci muhimmin sashi ne na shirin aikin.

Mafarkai masu daɗi,
Michael J. Breus, PhD, DABSM
Likitan Barci ™
www.thesleepdoctor.com