Yadda Maza da Mata ke aiwatar da Tsoron Tunawa

Daga Ma'aikatan Brain & Halayen

Maza da mata suna da saukin kamuwa da rauni-da rikice-rikice masu alaƙa da damuwa kamar tashin hankali da tashin hankali bayan tashin hankali (PTSD), binciken da ya gabata ya bayyana. Misali, mata suna haɓaka PTSD sau biyu na maza. Masu bincike suna son sanin dalilin hakan.

Yawan shaidu da ke ƙaruwa yana nuna cewa tsarin maza da na mata yana tsoron tunawa daban. Sabuwar bincike a cikin beraye daga ƙungiyar da 2016 BBRF Young Investigator Elizabeth A. Heller, Ph.D., na Jami'ar Pennsylvania, ta kafa wasu hanyoyin da abin ya ƙunsa. Fahimtar waɗannan hanyoyin na iya taimakawa a nan gaba ci gaba na takamaiman jinsi don rikicewar damuwa.

An ba da rahoton sabon binciken ƙungiyar akan layi a cikin Ilimin Halittu na Halittu a ranar 5 ga Disamba, 2018. Suna ba da shawarar cewa tsara tsarin halittar da ake kira Cdk5 shine muhimmin tushen bambancin yadda maza da mata ke aiwatar da fargabar tunawa. An ga bambance -bambance a cikin hippocampus na kwakwalwa, cibiyar samar da ƙwaƙwalwar ajiya, koyo, da daidaitawar sarari.

Juyin Halitta ya haifar da hanyoyi iri -iri ta inda sel ke sarrafa ayyukan kwayoyin halittar su - yadda suke kunna su da kashe su a takamaiman lokuta. Tsarin sarrafawa wanda ya dace da Cdk5 da sarrafa tunanin tsoro ana kiransa tsarin tsarin halittu. Irin wannan tsari na tsarin halitta shine sakamakon gyaran kwayoyin halitta, wanda ake kira alamomin epigenetic, ana ƙarawa ko cire su daga jerin DNA waɗanda ke "fitar da" kwayoyin halitta. Ta ƙarawa ko rage alamun asalin halitta, sel suna iya kunnawa ko rufe takamaiman kwayoyin halitta.

Amfani da beraye a matsayin mataimakan mutane - kwakwalwar berayen tana da kamanceceniya ta fannoni da yawa, gami da tsarin sarrafa kwayoyin halitta - Dr. Heller da abokan aikinta sun gano cewa dawo da tunanin tsoro na dogon lokaci yana da ƙarfi a cikin maza fiye da na mata. Dalilin: ƙara kunnawa Cdk5 a cikin maza, wanda ke haifar da alamun epigenetic. Kunnawa yana faruwa a cikin ƙwayoyin jijiya a cikin hippocampus.

Ta amfani da dabarar labari mai suna epigenetic editing, Dr. Heller da abokan aiki sun sami damar gano takamaiman rawar mace na Cdk5 kunnawa don raunana dawo da tunanin tsoro. Wannan yana da sakamako na takamaiman mace a cikin jerin ayyukan halittu bayan kunnawar kwayar halitta.

Waɗannan binciken wani ɓangare ne na fahimtarmu game da bambance -bambancen jima'i a cikin ilimin halittar yadda ake tunawa da abubuwan tsoro kuma suna ba da shawarar dalilin da yasa jima'i muhimmin abu ne a cikin kwakwalwa da rikicewar halayen da suka shafi tsoro da damuwa, kamar PTSD, ɓacin rai, da damuwa.